From the Writer’s Almanac:
Today is Election Day. It’s the 56th presidential election of the United States, and today is the first time in more than 50 years that neither the sitting president nor the sitting vice president is a candidate on his party’s ticket in the new presidential election. It’s also the very first time in history that the two main candidates for president are both sitting senators. The last sitting senator to be elected U.S. president was JFK in 1960.
I do believe this may also be the first time in history that the two major party candidates are both left-handed. But I haven’t confirmed that.